After CXCL8 binds to the receptor CXCR1/2, it can directly act on vascular endothelial cells or enhance the activity of MMP-2/9, which promotes the secretion of a large amount of VEGF and enhances its activity, inducing the formation of new blood vessels and increasing vascular permeability, further providing nutritional support for the proliferation and migration of ovarian cancer cells (161, 162). The gene discussed is CXCR1; the disease is ovarian cancer.