CXCL8 activates multiple downstream signaling pathways by binding to the cell membrane surface receptor CXCR1/2 of various cells (tumor cells, T cells, mast cells), which promotes tumor cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) and angiogenesis, further leading to tumor progression (21–24). This evidence concerns the gene CXCL8 and neoplasm.