In addition, the CXCL8/PI3K/PKB signaling pathway is also over-activated in gastric cancer, ovarian cancer, colorectal cancer, which can promote cell proliferation, metabolic reprogramming, regulate angiogenesis, induce EMT, and improve the infiltration ability of cancer cells (22, 62, 66–70). This evidence concerns the gene CXCL8 and colorectal cancer.