In gastric cancer, PMCs can synthesize inflammatory factors and angiogenic factors, such as VEGF, fibroblast growth factors (FGF), etc. (141), which further promotes matrix remodeling and angiogenesis to change the peritoneal structure, destroying the intact mesothelial monolayer and leading to the formation of a large number of matrix deposits in the submesothelial dense area. This evidence concerns the gene VEGFA and gastric cancer.