Meanwhile, ten key hub genes (AHNAK2, GPC2, DBNDD2, OLFM1, SCRG1, TNFAIP8L2, FILIP1L, CYSTM1, PARM1, and NCAPG) are determined using the Friend analysis, which is associated with the prognosis of STS. This evidence concerns the gene FILIP1L and telomere syndrome.