Meanwhile, ten key hub genes (AHNAK2, GPC2, DBNDD2, OLFM1, SCRG1, TNFAIP8L2, FILIP1L, CYSTM1, PARM1, and NCAPG) are determined using the Friend analysis, which is associated with the prognosis of STS. The gene discussed is TIPE2; the disease is telomere syndrome.