KEAP1 and cardiovascular disorder: As Nrf2 plays a critical role in regulating oxidative stress within cells, once oxidative stress occurs, Nrf2 translocates into the nucleus after dissociating from Keap1 due to the oxidation of the active site of Keap1, triggering the expression of different antioxidant genes; in addition, Nrf2 signaling pathway activation can efficiently preserve cellular redox homeostasis and modulate apoptotic protein levels with an efficient anti-inflammatory function, which helps alleviate myocardial infarction and other cardiovascular disorders (Wu et al., 2022) (Saha et al., 2020).