NFE2L2 and Hypertension: On the other hand, the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) antioxidant pathway activation displayed a protective effect against cardiovascular diseases, including hypertension, myocardial ischemia, and reperfusion myocardiopathy injury (Barančík et al., 2016).