First, we found an association between the cuproptosis score and COAD prognosis; based on this finding, the prognostic CRLs in COAD were obtained by the WGCNA and COX regression analysis, and the model contained AC008494.3, EIF3J-DT, AC016027.1, AL731533.2, and ZEB1-AS1. Here, ZEB1 is linked to colon adenocarcinoma.