POLE and neoplasm: Most of these genes are involved in DNA repair/modification processes (GO:0006259; TRRAP, SETDB1, POLE, TET1, RECQL4, PML, TFRC); chromosome organization (GO:0051276; STAG1, SMARCA4, TRRAP, SETDB1, POLE, TET1, RECQL4, PML); and cell cycle process (GO:0022402: STAG1, TRRAP, BIRC6, POLE, RECQL4, PML), which might provide clues about mechanisms of tumor cell evasion from tumor suppressors, therapy, or the patient’s immune response.