Wound dehiscence, ALP increased,Blood bilirubin increased, Hypertriglyceridemia, Anorexia,Weight loss, Pneumothorax,Platelet count decreased, Diarrhea, Hand-foot syndrome, Pain in extremity,AST increased, ALT increased, Leukopenia, Rash, Mucositis oral, Hypertension, Abdominal pain, Toothache,Non-cardiac chest pain, Hypothyroidism, Blood LDH increased, Proteinuria, Cough, Nausea, Vomiting, Hair color changes,Hemorrhoidal hemorrhage, Fatigue,Peripheral neuroinflammation. The gene discussed is GPT; the disease is hypothyroidism.