HSPG2 and neoplasm: Therefore, TKIs suppress the tumor angiogenesis and induce the tumor cell apoptosis, thus to inhibit the growth and metastasis of tumor cells by inhibiting the abnormal activity of tyrosine kinase through single or multiple targets via the four signaling pathways (JAK/STAT, RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, and PLC/PIP2/DAG/PLK) (14).