Wound dehiscence, ALP increased,Blood bilirubin increased, Hypertriglyceridemia, Anorexia,Weight loss, Pneumothorax,Platelet count decreased, Diarrhea, Hand-foot syndrome, Pain in extremity, AST increased, ALT increased, Leukopenia, Rash, Mucositis oral, Hypertension, Abdominal pain, Toothache, Non-cardiac chest pain, Hypothyroidism, Blood LDH increased, Proteinuria, Cough, Nausea, Vomiting, Hemorrhoidal hemorrhage, Fatigue, Peripheral neuroinflammation. This evidence concerns the gene GPT and hypothyroidism.