ST6Gal-I sialyltransferase, an enzyme upregulated in numerous cancers has been reported to promote survival and resistance in ovarian, pancreatic, and colorectal cancers via hypersialylation of tumor necrosis factor receptor 1 (TNFR1) and Fas Receptor (FasR) death receptor (36, 37). This evidence concerns the gene TNFRSF1A and colorectal cancer.