After observing that CASD1 knockout promotes cell survival and proliferation in cancer cell lines, we investigated the clinical relevance of CASD1 and SIAE expression in clinical samples by examining the relationship between overall patient survival and CASD1 and SIAE mRNA expression in lung adenocarcinoma (LUAD) and colon adenocarcinoma (COAD) clinical samples from The Cancer Genome Atlas (TCGA). This evidence concerns the gene CASD1 and lung adenocarcinoma.