In addition, cells immunoreactive for the proliferation marker (PCNA and Ki-67) decreased significantly in the treated tumor masses compared with the normal saline-treated tumor masses in the middle of the treatment, and the PDX models with pCR resulted in the lowest PCNA levels and Ki-67 in the both middle and end of treatment (Figures 7, 8). The gene discussed is MKI67; the disease is neoplasm.