ETV6 is involved in over 30 translocation partnerships in leukemia and MDS including fusions with PDGFRB, AML1, MN1, JAK2, ASC2, ABL2, BTL, ARNT, MDS2, PER1 and an ETV6-RUNX1 fusion seen in over 22% of childhood B-ALL (79, 85). This evidence concerns the gene RUNX1 and myelodysplastic syndrome.