Interestingly, analysis of heptad expression identified RUNX1, FLI1, LMO2, GATA2, ERG and LYL1 levels were significantly higher in groups of poorer overall survival, suggesting that high expression levels of the heptad contribute to the relative immaturity or stemness of the AML transcriptome (4, 39). The gene discussed is ERG; the disease is acute myeloid leukemia.