GATA1 and leukemia: (Figure 2, Table 1) GATA1s (GATA1 “short” - lacks N-terminal domain) has been extensively used as a biological tool to investigate the effect of GATA1 aberration on hematopoiesis, where LOF GATA1 initiates the arrest of both primitive and definitive erythropoiesis by inducing apoptosis in erythroid progenitors and phenotypically displays BMF syndromes (e.g., disordered terminal platelet maturation) without manifesting into leukemia (162, 174).