- abnormal megakaryocyte, B cell differentiation, erythropoiesis, thrombopoiesis and hematopoiesis, thymocyte, B cell, megakaryocyte, erythroid progenitor, erythrocyte, granulocyte, NK and monocyte cell numbers, spleen and megakaryocyte, proerythroblast and leukocyte morphology- decreased B cell proliferation, hematocrit and IgG1 and IgG3 levels- anemia and thrombocytopenia. The gene discussed is IGHG3; the disease is anemia.