- Abnormal IgA and IgE levels- Epistaxisl, Joint hemorrhages, Persistent bleeding after trauma, Bruising susceptibility, Petechiae, Anemia of inadequate production, Poikilocytosis, Acanthocytosis, Leukocytosis and Thrombocytopenia- Increased megakaryocyte colony forming unit counts. Here, IGHE is linked to Constitutional hemolytic anemia due to acanthocytosis.