GATA2 and lymphedema: For instance, patients with GATA2 deficiency syndrome may develop different syndromic features under different stresses such as BMF or lymphedema with persistent infections or inflammation, myeloid malignancy with biological (e.g., cytosine deamination with aging) or chemical-induced acquisition of pathogenic mutations, hearing loss due to disruption in development of ear structures due to aminoglycoside antibiotic or stochastic events leading to urinary system malformation (169).