STUB1 and Miyoshi myopathy: [9,266] It might be anticipated that those predisposition genes, such as TFs and/or epigenetic regulators, that have an impact on a multitude of pathways during hematopoiesis are more likely to impact pathways predisposing to CHIP mutation accumulation such as DNA damage pathways, which has been implicated in RUNX1 FPD-MM.