IKZF1 and cancer: These include missense variants at DNA contact residues that are still able to dimerize with wildtype IKAROS but are unable to bind target DNA (103, 110), haploinsufficiency with deletion of one IKZF1 allele (103), differential expression in gene networks involved in cancer, cell signaling, apoptosis, and hematopoiesis (111) and transcription, dimerization, subcellular localization, and cell adhesion LOF (107, 108).