ERBB2 and lung adenocarcinoma: We further applied the modified scFEA on TCGA pan-cancer transcriptomics data of 11 cancer and subcancer types having matched adjacent normal controls, namely breast cancer (BRCA) luminal, her2-, and triple-negative (TNBC) subtypes, colon adenocarcinoma (COAD), head and neck cancer (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), prostate adenocarcinoma (PRAD), stomach adenocarcinoma (STAD), and thyroid carcinoma (THCA), totaling 5,253 samples (see details in Methods).