P/LP variants in novel, candidate cancer genes (class 4) including SF3B4 (Fig. 3B – Patient 4093), FMN2 (Fig. 3B – Patient 4093), and MMP13 (Supplementary Fig. S7C – Patient 1774) are found in 21% (3/14) of patients with cancer (Supplementary Table S5E and S5F). The gene discussed is MMP13; the disease is cancer.