Compared with the variant TP53 patients who developed cancer, the wildtype TP53 patients who developed cancer were enriched for P/LP variants in genes found to be upregulated by reactive oxygen species (ROS; freq = 9%; FDR = 0.11; Supplementary Fig. S6) and genes important for mitotic spindle assembly (freq = 14%; FDR = 0.11; Supplementary Fig. S6). This evidence concerns the gene TP53 and cancer.