CHD4 and cancer: Recurrent P/LP variants were identified in individuals diagnosed with cancer from distinct families, in the following cancer genes: BRCA1 (n = 3), LZTR1 (n = 3), HNF1A (n = 2), CHEK2 (n = 2), MITF (n = 2), and CHD4 (n = 2; Fig. 2D).