TP53 and cancer: Pathway analysis of the P/LP SNVs, indels, and SVs across all genes revealed that the p53 pathway (freq = 13%; FDR = 0.19) and the epithelial-to-mesenchymal transition pathway (freq = 13%; FDR = 0.10) were the most frequently mutated pathways across patients with LFS with cancer (Supplementary Fig. S3).