Eight of the cis-CSCE lie in cancer genes on our Tier 3 list, including ASXL1 (qCSCE = 1.04 × 10−2;rhoCSCE = −0.371) and ETV6 (qCSCE = 2.41 × 10−2;rhoCSCE = 0.386;Fig. 4C). The gene discussed is ETV6; the disease is cancer.