TP53 and ovarian carcinoma: Finally, the P15 ovarian tumor, for which the C and S samples were collected from the left and right ovaries, respectively, arose from whole-genome doubling along with TP53 clonal mutation and exhibited a BRCAness signature (HRD), concordant with an elevated genomic instability previously reported in serous high-grade ovarian cancers (Fig. 4C; Supplementary Fig. S16).