SMAD4 and colorectal neoplasm: At the clinical level, TCGA analysis shows that RAB10 is significantly less expressed in colorectal tumors with a gain of SMAD4 as compared with tumors with deep deletion of SMAD4 (*, P = 0.0391 gain vs. deep deletion; Fig. 5A), suggesting that RAB10 expression is upregulated in absence of SMAD4.