In the immune AOIs, there was a strong positive correlation between the IFI30 gene and protein targets associated with MHC class II presentation on macrophages (CD68, CD14, HLA-DR), Th cells (CD4, CD127), dendritic cells (S100B) and tumor cells or activated APCs (B7-H3; Supplementary Fig. S13). Here, S100B is linked to neoplasm.