TILs from patient 1913 were cocultured with their autologous tumor cell line for 16 hours and PD-1+ 4-1BB+ CD8+ T cells were sorted and infected with Sendai virus containing four Yamanaka factors and SV40 large T antigen to facilitate the reprogramming (Fig. 3A; Supplementary Fig. S3A). The gene discussed is PDCD1; the disease is neoplasm.