Overexpression of NDRG1 significantly downregulated chemosensitivity to cisplatin in lung cancer A549 cells; at the same time, the author informs that overexpression of NDRG1 in lung cancer A549 cells significantly downregulated cisplatin-induced cytotoxicity (Du et al., 2018). The gene discussed is NDRG1; the disease is lung carcinoma.