For that, they obtained a conditional overexpression of the mitochondrial fatty acid shuttling enzyme carnitine palmitoyl-transferase 1A (CPT1A) in renal tubular epithelial cells (TECs), using a transgenic mouse model based on the doxycycline-inducible transgenic system Tet-On controlled with the transactivator (rtTA2s-M2) driven by the paired box 8 (Pax8) promoter, which significant mitigated renal fibrosis. The gene discussed is CPT1A; the disease is renal fibrosis.