Alterations found in the levels of specific compounds (citric acid, acetylspermidine, methyladenosine, cholesteryl esters, triglycerides, glycine-betaine, amino acid metabolism, and hydroxylated and acetylated lysine derivatives) withing fibrosis with and without Cpt1a OE, lend the ground to investigate in depth their pathogenetic role in kidney fibrosis. The gene discussed is CPT1A; the disease is fibrosis.