SIRT3 and Parkinson disease: In addition, it is also suggested that the accumulation of α‐syn in PD inhibits mitochondrial function by affecting the level of mitochondrial sirtuin 3 protein, an NAD+‐dependent deacetylase that regulates the acetylation/deacetylation level of complex I.201The sirtuin 3 in mitochondria has been proven to prevent dopaminergic neuron loss in a rodent model of PD.202