A synergistic role of Ang-2 and VEGF-A in vascular de-stabilization has previously been explored in JR5558 mice, a mouse model of spontaneous choroidal neovascularization (sCNV) in which mice develop subretinal neovascularization and fibrotic lesions resembling human nAMD (Nagai et al., 2014; Rossato et al., 2020). This evidence concerns the gene ANGPT2 and choroidal neovascularization.