In mice, homozygous deletion of Trpm7 is embryonic lethal, and Trpm6 knockout mutants exhibit exencephaly and/or spina bifida occulta (Walder et al., 2009; Woudenberg-Vrenken et al., 2011; Jin et al., 2008). This evidence concerns the gene TRPM6 and Spina bifida occulta.