Human CLDN16 and CLDN19 variants are associated with familial hypomagnesemia with hypercalciuria (FHHNC; OMIN 248250), and a missense variant in CLDN19 has been associated with NTDs (Baumholtz et al., 2020). This evidence concerns the gene CLDN16 and familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis.