MYC and neoplasm: In general, genes highly expressed in MELK KO cells showed enrichment for gene sets associated with cell proliferation (i.e., G2–M checkpoint genes, E2F target genes, MYC target genes, and mitotic spindle genes), and high expression of MELK-induced high levels of expression of STAT5 and NFKB target genes, as well as genes associated with concepts generally involved in tumor progression and metastasis (i.e., angiogenesis, hypoxia, coagulation, and apical junction).