MELK and malignant colon neoplasm: Recent studies also showed that MELK is overexpressed in other types of cancers, such as brain cancer, colon cancer, glioblastoma, and melanoma (17, 38–40), and high levels of MELK are correlated with tumor grade, poor prognosis, radioresistance, and recurrence in multiple cancers (19, 21, 41–45).