What’s more, Zhang showed that macrophage-derived exosomes could facilitate osteosarcoma cell progression both in vitro and in vivo and revealed the mechanism by which exosomal lncRNA-LIFR-AS1 promoted osteosarcoma cell proliferation and invasion, and inhibited cell apoptosis via the miR-29a/NFIA axis [86]. The gene discussed is LIFR; the disease is osteosarcoma.