Endo-Munoz et al. reported that metastatic osteosarcoma-derived EVs contain the urokinase plasminogen activator (uPA) and the uPA receptor (uPAR) at elevated levels, and that these EVs promote the conversion of non-metastatic osteosarcoma cells to a metastatic phenotype [47]. The gene discussed is PLAU; the disease is osteosarcoma.