Furthermore, Garimella et al. demonstrated that extracellular membrane vesicles derived from osteosarcoma cells contain matrix metalloproteinases-1 and −13 (MMP-1, −13), TGF-β, CD-9, and receptor activator of nuclear factor-kappa B ligand in abundance, and promote osteoclastogenic and bone destruction [60]. Here, TGFB1 is linked to osteosarcoma.