Bone marrow mesenchymal stem cell (BMSC)-derived exosomes express lncRNA-PVT1 at high levels, which can be transported to osteosarcoma cells; the transported PVT1 promotes tumor metastasis by sponging miR-183-5p, promoting the expression of ERG, and inhibiting the ubiquitination of ERG in osteosarcoma cells [46]. The gene discussed is ERG; the disease is neoplasm.