158 Wan Wan X X Wen Wen JJ JJ Koo Koo SJ SJ Liang Liang LY LY Garg Garg NJ NJ SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress During Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress During Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease PLoS Pathog PLoS Pathog 2016 2016 12 12 10 10 e1005954 e1005954 10.1371/journal.ppat.1005954 10.1371/journal.ppat.1005954 27764247 27764247. The gene discussed is SIRT1; the disease is American trypanosomiasis.