Similar to cytoplasmic expression of MHCII in CHL (Diepstra et al., 2007) and in diffuse large B cell lymphoma (Kendrick et al., 2017), cytoplasmic CD30 expression in CHL may represent a distinct biology, as a possible response to signals from the microenvironment. The gene discussed is TNFRSF8; the disease is classic Hodgkin lymphoma.