TNFRSF8 and Hodgkins lymphoma: While CD30 expression has been described as the critical immunophenotypic characteristic of RSCs, there are reports of heterogeneous expression and even CD30-negative Hodgkin lymphoma cases (Miettinen, 1992; von Wasielewski et al., 1997; Rüdiger et al., 1998a,b; Flangea et al., 2006; Salama et al., 2010; Ahmed et al., 2011).