In one case (3%) of CHL and in three cases (75%) of NLPHL, the tumor cells showed complete absence of CD30 staining (Fig. 3G,H), whereas 28 cases of CHL (97%) and one case (25%) of NLPHL expressed CD30 to various degrees (p=0.01; Bayesian probability that CHL exhibits greater expression=0.99). This evidence concerns the gene TNFRSF8 and neoplasm.