OGA and neurodegenerative disease: Imaging O-GlcNAcase OGA by positronemission tomography(PET) could provide information on the pathophysiological pathwayof neurodegenerative diseases and important information on drug-targetengagement and be helpful in dose selection of therapeutic drugs.Our aim was to develop an efficient synthetic method for labelingBIO-1819578 with carbon-11 using 11CO for evaluation ofits potential to measure levels of OGA enzyme in non-human primate(NHP) brain using PET.