Some cytokines and molecules, such as C-X-C motif chemokine 10, interferon-gamma, interleukin (IL)-1β, IL-6, IL-8, IL-17, and tumor necrosis factor-alpha, are induced by infection and play an important role in the pathogenesis of both acute and persistent sequences of symptoms associated with COVID-19. The gene discussed is TNF; the disease is COVID-19.