A recent examination of the spatiotemporal distribution and pathomorphological features in the CNS following intranasal infection with several SARS-CoV-2 variants showed that the original virus, as well as alpha, beta, and delta infection were restricted to neurons and appeared to spread from the olfactory bulb mainly in basally oriented regions in the brain and into the spinal cord, independent of ACE2 expression and without evidence of neuronal cell death, axonal damage, or demyelination [27]. This evidence concerns the gene ACE2 and infection.