IFNA1 and infection: Winkler et al. [29] thoroughly analyzed lung inflammation and damage following SARS-CoV-2 infection with the original virus at several time points, showing high levels of viral RNA and viral titers at several time points following infection, decline in pulmonary function, as well as extensive upregulation of the innate immune response, including hundreds of DEGs, many of which associated with IFN signaling, nuclear factor-κB-dependent cytokine responses, or leukocyte activation [29].