Though this pathway’s title highlights “...Pathogenesis of Influenza”, the molecules involved in this pathway are very much relevant for SARS-CoV-2, as well, including many cytokines and innate immune molecules, namely, IFNβ, IL1, IL6, IL10, Cxcl10, Cxcl2, IRF3, IRF7, IRF9, etc. SARS-CoV-2 infection is a potent inducer of proinflammatory cytokines, and as such, strong upregulation and activation of this pathway upon SARS-CoV-2 infection by any of the tested variants is expected [12,31]. The gene discussed is IRF3; the disease is influenza.