Using human glioma cells U251, they found that HERV-W env overexpression regulates a number of molecular markers associated with schizophrenia, such as the neurotrophic factor derived from the brain (BDNF), the N2-receptor receptor type of neurotrophic tyrosine kinase type 2 (NTRK2, also known as TrkB), and dopamine receptor D3, and increases cAMP phosphorylation. The gene discussed is NTRK2; the disease is central nervous system cancer.