MAPT and Alzheimer disease: The present study aims to address these knowledge gaps by assessing the prevalence of Aβ and p-Tau pathology across AD-sensitive brain regions, such as the prefrontal neocortex, putamen, basal-temporal neocortex, and hippocampus, among middle aged to older (age 50+ years) postmortem PWH from the National NeuroAIDS Tissue Consortium (NNTC).