These findings suggest that, among intratumoral IgG+ ASCs in HPV+ HNSCC, bystander responses directed against common human pathogens such as influenza are relatively rare and that most IgG+ ASCs might be directed against tumor antigens, which is in stark contrast to the ample presence of bystander CD8+ TILs in most malignancies [122,123,124,125,126,127]. Here, CD8A is linked to neoplasm.