CD8A and head and neck squamous cell carcinoma: Notably, a recent study identified CD8+ TIL responses against HPV E1, E2, and E6 [133], further supporting the notion that “non-classical” HPV antigens such as E1, E2, E4, and E5 are targeted by a substantial portion of HPV-specific CD8+ TILs and should thus not be neglected in the development of novel therapeutic interventions for HPV+ HNSCC.