UA has demonstrated its anti-cancer effect in several cancer types including breast cancer, colorectal cancer, ovarian cancer, lung cancer, and prostate cancer by targeting multiple signaling pathways such as MAPK, NF-κB, JAK/STAT, PI3K/Akt/mTOR, and Wnt/β-catenin [32]. This evidence concerns the gene NFKB1 and colorectal cancer.