Ryu et al. [199], in a study with mice and mouse macrophages after mCoV-A59 infection replicating the clinical features of COVID-19, observed that administration of a ketogenic diet for 5 days in an aging mouse model of mCoV-A59 infection, significantly decreased NLRP3 mRNA and caspase-1 in the lung, visceral adipose tissue (VAT), and hypothalamus, and inflammasome activation in the VAT. The gene discussed is NLRP3; the disease is COVID-19.