Some other anti-tumorigenic effects of neutrophils include an inhibiting angiogenesis, invasion and migration of tumor cells by expressing antiangiogenic factors such as angiostatin, endostatin and thrombospondin-1 [34], the prevention of metastatic colonization by blocking adhesion molecules on endothelial cells or by competing with tumor cells for attachment sites [34]. The gene discussed is THBS1; the disease is neoplasm.