These cytokines can induce the expression of pro-inflammatory molecules and cytotoxic mediators on neutrophils, such as ICAM-1, IP-10/CXCL10, TNF-α, elastase, and cathepsin G. N1 neutrophils can be generated by exposure to tumor cell lysates or apoptotic tumor cells, which can stimulate the production of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) by natural killer (NK) cells and T-cells [36,37]. Here, TNF is linked to neoplasm.