Since expression of mucosal vascular addressin cell adhesion molecule-1 (MADCAM-1) represents a reliable, specific, and early marker of IBD-related inflammation, Truffi et al. investigated the use of PLGA-PEG micelles conjugated with monoclonal antibodies against MADCAM-1 and loaded with manganese oxide (MnO) nanocrystals as contrast enhancers in magnetic resonance imaging (MRI). The gene discussed is MADCAM1; the disease is inflammatory bowel disease.