In addition, further studies revealed that Pt(IV)/CQ/PFH NPs-DPPA-1 can reprogram the metabolic pathways of immature dendritic cells and TAMs to reverse the tumor immunosuppressive microenvironment, including promoting the differentiation of immature stump cells (iDCs) into mature dendritic cells (mDCs), promoting the polarization of M2-type macrophages into M1-type macrophages, increasing the proportion of CD8+ IFN+ T cells, and promoting the secretion of immune cytokine IL-12. This evidence concerns the gene CD8A and neoplasm.