Therefore, the ability of CRT-NPs to reprogram the tumor microenvironment via MDSCs likely improved both the infiltration and functional capacity of antigen-presenting cells [57], which then correlated with the overall increase in CD8+ T cell infiltration and anti-CTLA4 synergy, improving the infiltration of granzyme-positive CD8+ and CD4+ T cells and reducing the CD4+ Foxp3 cell population [10,58]. This evidence concerns the gene CD8A and neoplasm.