RNPC3 and neoplasm: Previously, they had already designed a disulfide-bridged biguanidyl adamantine (Ad-SS-GD) with a β-cyclodextrin-conjugated low-molecular-weight polyethyleneimime (CP) nanocomplex with high efficiency for in vitro cytosolic delivery of RNP, and it was able to inhibit tumor growth and metastasis in the tumor-bearing CRC mouse models [112].