Evidence of a decreased expression of cyclin D1 and phospho-IκB-α after curcumin treatment of mice bearing head and neck squamous cell carcinoma was published four years later [24].Over the next 8 years, these discoveries were further confirmed in many other rodent and human tumor models, and the number of reports published annually increased exponentially. The gene discussed is CCND1; the disease is head and neck squamous cell carcinoma.