PKM and cervical carcinoma: However, the available data is not necessarily unequivocal and asks for a careful interpretation with respect to the specifics of the cancer’s origin: high expression of PKM2 was shown to be associated with resistance to cisplatin in bladder cancer [157], but, on the other hand, it enhances response to cisplatin in cervical cancer through a complex interaction with the mTOR signaling pathway [158].