In order to explore the effect of chemosensitization of the whole extract of the C. longa, and then each active compound separately: curcumin, bis-curcumin and demethoxycurcumin, with respect to cancer cell response to 5-FU and lactate metabolism, Li et al. [142] used the 5-FU resistant colon cancer cell line, HCT8, previously shown to overexpress MCT1 [143]. This evidence concerns the gene SLC16A1 and cancer.