A second report documented the inactivation of the JAK2/STAT3 pathway in a liver cancer model, in a similar fashion: a curcumin analog, GL63, contributes to a decreased expression of circZNF83, a sponge for miR-324-5p, whose target is cyclin-dependent kinase 16 (CDK16) [44]. The gene discussed is STAT3; the disease is liver cancer.