In another model, application of curcumin was shown to have a potential for shifting the intracellular pH of cancer cells toward acidity through decreasing both MCT1 and Na+/H+ antiporter NHE1 (SLC9A1—solute carrier family 9 member A1 [144], which also may contribute to curcumin’s chemosensitizing properties. The gene discussed is SLC9A1; the disease is cancer.