In two human cell lines originating from glioblastoma (U-87 MG) and neuroblastoma (SH-SY5Y), exposure to curcumin and its analogue, MS13, induced significant changes in the levels of various proteins, including a few involved in metabolic regulation, namely, glyceraldehyde-3-phosphate dehydrogenase (GAPDH; decrease in both MS13-treated cell lines) and phosphoglycerate kinase 1 (PGK1) in MS13-treated SH-SY5Y [128]. The gene discussed is PGK1; the disease is neuroblastoma.