The most recent data show that STAT-3—mediated ALDOA (fructose-bisphosphate aldolase A), binding to HIF1α (which itself contributes to multiple resistance in cancer) strongly contributes to development of chemoresistance against cisplatin (models: breast cancer cell line MCF-7 and xenografts MDA-MB-231 [136]. Here, STAT3 is linked to breast cancer.