However, MET mutations are rare (P97K/Q, I865F) in NSCLC with the most-common ones that affect the semaphorin domain (avoiding the growth factor binding), the juxtamembrane domain (altering the actin cytoskeleton of the cell), and the TK domain (with the consequent constitutive activation of the receptor, even in the absence of its ligand) [101,103,124,125,126]. Here, MET is linked to non-small cell lung carcinoma.