IL6 and neoplasm: Another study modelled human multiple myeloma plasma cell tumours using the MISTRG models with an additional knock-in allele to express human IL-6 and recapitulated the entire genetic diversity of the primary tumour, witnessing the improved growth of non-malignant cells from the primary tumour over other models, likely due to enhanced human haematopoiesis, even in the absence of human foetal tissue [135].