More recent studies have demonstrated the immunosuppressive and exhaustive phenotypes of ovarian cancers and demonstrated the efficacy of using dual blockade with anti-LAG-3 and anti-PD-1 in murine models with a significantly higher number of T cells in the TME, enhanced CD8+ TIL functions, and a reduced subset of Treg cells [93]. The gene discussed is PDCD1; the disease is ovarian carcinoma.