Triple therapy using pembrolizumab, bevacizumab (anti-vascular endothelial growth factor (VEGF)), and the Stat inhibitor C188-9 resulted in an improved combinatorial effect, with the lowest level of proliferation and evidence of reduced angiogenesis, thus significantly increasing the efficacy of the anti-HCC response compared with the results of traditional therapy [48]. Here, VEGFA is linked to hepatocellular carcinoma.