HLA-C and graft versus host disease: The possibility of PBMCs and tumour tissues originating from the same patients proved to be a key advantage of the Hu-PBMC model, but resulted in only a partial reconstitution of the human immune system in the peripheral blood of the mice, with most cells being CD3+ T cells that eventually interacted with major histocompatibility complex (MHC) molecules in mice and led to graft-versus-host disease (GvHD) [20].