In summary, the present study provides the first evidence that MGF exerts a significant neuroprotective effect against the FA-induced cognitive impairment of mice and HT22 cell damage by repressing the crosstalk between ERS and downstream Tau-associated kinases (GSK-3β and CaMKII), which is considered a potential therapeutic target in the treatment of AD and diseases caused by FA pollution. Here, GSK3B is linked to Cognitive impairment.