STAT3 and lip and oral cavity carcinoma: One of these compounds, malvidin (malvidin-3-glucoside), showed inhibitory activity against (Signal transducer and activator of transcription 3) STAT-3 within the oral cancer cell line (SCC131) by suppressing the phosphorylation and nuclear translocation of this factor, which resulted in cell cycle arrest and mitochondrial-mediated apoptosis [120].