Berries’ mechanisms of action in oral cancer include: (i) the inhibition of inflammation through interference with the nuclear transcription factor NF-κB, (ii) effects on proliferation by interfering with the MAP kinase pathway, (iii) reduction in resistance by interfering with the expression of detoxification enzymes, (iv) interference with the β-catenin signaling pathway, (v) modulation of apoptosis, and (vi) modulation of the antiapoptotic and anabolic pathways of PI3K/AKT/mTOR. The gene discussed is AKT1; the disease is lip and oral cavity carcinoma.