Consistently, Ashokkumar and Sudhandiran [42] evaluated the protective effect of the flavonoid luteolin in a 17-week mouse model of colon carcinogenesis induced with AOM, describing that luteolin reduced cell proliferation, evidenced by lower AgNOR, PCNA, and β-catenin in contrast with the positive control. The gene discussed is PCNA; the disease is infectious otitis media.