IL1B and medical procedure: APAP-induced uterus toxicity is correlated with inflammation because the activated metabolite of APAP (NAPQI) leads to the infiltration of inflammatory cells and overexpression of cytokines (such as IL-1β and IL-6), which culminate in inflammation and injury of the liver [37], kidney [38], and brain [39], released from 4 to 24 h after an overdose of APAP exposure [40].