LEP and obesity due to melanocortin 4 receptor deficiency: As anti-obesity agent, it decreases weight gain and adipose tissue weight by decreasing calorie intake and AMPK activation in the liver, white adipose tissue, and skeletal muscle, reducing the absorption of lipids, cholesterol, triacylglycerols (TAGs), and leptins, stimulating energy expenditure and fat oxidation, and increasing the level of high-density lipoproteins and fecal excretion of lipids [150,151,152].