In C57BL/6J mice fed a high-fat high-fructose diet (HFHFD), supplementation with EGCG showed beneficial effects on circadian misalignment, obesity, insulin resistance, and lipid metabolism by normalizing the expression of the clock genes CLOCK and Bmal1 and by regulating the levels of SIRT1 and PGC1α. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.