As indicated in this figure, three metabolic alterations caused by VEGFR2 suppression: abrogation of PI3K/AKT/mTOR pathway, leading to angiogenesis inhibition and apoptosis promotion in endothelial and tumor cells; suppression of PLCγ/ERK1/2 pathway, resulting in antiproliferative effects; and suppression of metastasis-related mediators in 4T1 MCT cells. Here, AKT1 is linked to neoplasm.