Figure 2C shows a considerable decrease in vessel density after C-VGB3 treatment (84% reduction, p = 0.02), while L-VGB3 was similar to the phosphate-buffered saline (PBS)-treated control. The tumor cell proliferation was analyzed using Ki67 immunohistochemical staining as an index of tumor cell proliferation. C-VGB3 decreased Ki67-positive cells compared to the control (60%, p = 0.04), whereas L-VGB3 was ineffective (Figure 2D). This evidence concerns the gene MKI67 and neoplasm.