Figure 3 shows diagrammatically representation of nanotechnology-assisted targeting of inva-sion/intravasation. These findings suggest that Nectin-4, by sensitising cancer cells to the chemotherapeutic drug 5-FU, plays a crucial role in the resistance of metastatic cervical cancer cells to therapy. Using miR-125b-5p, a therapeutic and MRI-visible theranostic nanomedicine platform, has been found to be effective in targeting EMT and CSCs in hepatocellular carcinoma (HCC) [79]. Here, NECTIN4 is linked to hepatocellular carcinoma.