For instance, a study revealed that the crude polysaccharides from C. pilosula could inhibit the proliferation of IL-4-induced M2-like TAMs and significantly increase the mRNA expression levels of IL-1, IL-6, iNOS, and TNF-α, thereby reducing the tumor volume in melanoma mice via repolarization of tumor macrophages [18]. This evidence concerns the gene NOS2 and neoplasm.