A total of 16 common genes, including EZH2, SCP2, ILK, CDK6, EGF, SPP1, PLOD3, SKIV2L, CXCL2, NISCH, ICAM1, SRC, CAT, COG7, BAX, and COG4, which are also involved in cholestasis, were identified under the treatment with the low dose of Hypericum extract. The gene discussed is SPP1; the disease is cholestasis.