SOAT1 and acute myeloid leukemia: Interestingly, in our previous studies, TQ induced SHP-1 hypomethylation and enhanced SHP-1 expression in MV4 -11 AML cells which led to growth inhibition and apoptosis enhancement [36], implying that TQ could be an effective anti-leukemia drug by targeting the epigenetically silenced genes that negatively regulate JAK/STAT in leukemia cells.