WT1 and chronic myelogenous leukemia, BCR-ABL1 positive: CML is associated with frequent mutations of genes involved in regulating the DNA methylation process, such as DNA-methyltransferases (DNMTs) mutations, including the DNMT1 gene, DNMT3A gene, and DNMT3B gene mutations [5], and DNA demethylases mutations, including Wilms Tumor 1 (WT1) mutation and Ten Eleven Translocation 2 (TET2) mutation [5,6].